Role of ions, lipids, serum and urinary protein profile in developing hypertension

Study was conducted to observe the relationship of ions with lipid profile and protein content of hypertensive patients. Lipid profile, ions and serum and urinary proteins were studied in patients with hypertension and compared with normal subjects. Serum cholesterol, triglyceride and LDL-chol were significantly increased, whereas the level of HDL-cholesterol was significantly decreased in patients as compared to their controls. Serum calcium was increased, whereas the level of serum magnesium was decreased as compared to control subjects. Serum protein level is non significantly decreased whereas serum albumin and urinary protein decreased significantly. Beside lipid profile, there may be a role of ions like calcium and magnesium as will as of protein in hypertension

Study the combined effects of amlodipine and simvastatin on lipid profile in Hypertensive obese patients

A study was conducted to evaluate the combined effect of Amlodipine and Simvastatin on the lipid levels of hypertensive obese patients. Amlodipine belongs to the dihydropyridine subclass of calcium antagonist whereas Simvastatin is a competitive inhibitor of HMG-CoA [3Hydroxy 3Methyl Glutaryl Coenzyme A] reductase. Three group of patients of both gender comprises 40 in each were included. Group A [hypertensive obese patients] was given amlodipine, group B [obese patients] was given simvastatin and group C [hypertensive obese patients] was given combination of amlodipine and simvastatin. Blood pressure was checked and tests for serum Cholesterol, serum Triglycerides and serum Lipoprotiens [HDL, LDL] was carried out by Standard kit methods [Merck]. The patients were evaluated three times i.e. before giving the medicines 0 week, at 6[th] and 12[th] week. The patients were advised to take fat free diet and a morning walk. Mean blood pressure of both male and female patients was significantly reduced. It was observed that combined therapy of Amlodipine and Simvastatin, significantly decreased the level of serum cholesterol, triglycerides and LDL-Cholesterol and significantly increased the level of HDL-Cholesterol in both sexes, but they did not show any significant synergistic effect as compared to the levels of these parameters in group A [amlodipine] as well as in group B [simvastatin]. A significant weight reduction is observed in male patients which may be due to low calorie diet and physical exercise. It is therefore concluded that synergism with Amlodipine and Simvastatin is not significant as the major action of Amlodipine is on blood pressure and the major effects of Simvastatin is on lipid profile and also reduced the body weight, if patients used calorie restricted diet with some morning walk

Aminoglycosides induced nephrotoxicity and its protection by nigella sativa

The major obstacle limiting the use of aminoglycoside, antibiotics has been and continue to be the possibility of drug induced ototoxicity and nephrotoxicity. Changes in biochemical parameters related to nephropathy before and after of nigella sativa is observed. Five Rabbits were included in the study. Nephrotoxicity was induced with gentatamycin. Extract of Nigella Sativa was given for 20 days and estimated the biochemical changes related to kidney function. Blood samples were taken before and after the administration of Nigella Sativa [at 11 days and 21 days]. It is therefore concluded that although nigella sativa shows a significant effect on nephrotoxicity induced by gentamicin but its effect on the level of serum calcium and cholesterol may be dangerous. However further research is needed on large number of rabbits to reach on a definite

Prokinetic effect of erythromycin on contractility of an isolated strip of rabbit's intestine compared with neostigmine and metoclopramide

Intestinal hypomotility is a major problem after surgery on gastrointestinal tract and in certain conditions. Prokinetic effect of erythromycin on ILEAL contractility on an isolated strip of rabbit's intestine was compared with that of neostigmine and metoclopramide. Effect of neostigmine is highly significant [P > 0.001] in increasing contractility in intestinal muscle strips Metoclopramide effectively increased contractility [P > 0.1] and erythromycin also significantly [P > 0.05] improved contractility. This study proved that erythromycin is a potent Prokinetic agent, which can be useful in conditions associated with gastrointestinal hypomotility